Jun 23, 2009 As we all know, propofol is an intravenous sedative currently favored in the ICU due to relatively short half-life and generally good side effect 

very few side effects and was not different from place- bo. However, no study has compared the efficacy of propofol with conventional antiemetic drugs.

Controversy exists regarding the effectiveness of propofol to prevent postoperative nausea and vomiting. This prospective, randomized, single-blinded study was designed to evaluate the antiemetic effectiveness of 0.5 mg/kg propofol when administered intravenously after sevoflurane- compared with desflurane-based anesthesia. DISCUSSION: A large proportion of practicing anesthesiologists use propofol for its antiemetic effect, sometimes in combination with other agents. A surprising number (62.5%) expect propofol to reduce PONV more than 60 min after induction dose.

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The antiemetic effect of propofol is attributed to modulation of subcortical pathways to inhibit nausea or its direct depressant action on the vomiting center . The results of our study are consistent with other studies, conducted in different settings, in terms of antiemetic rescue therapy requirements and trends of dexamethasone preventive effect [ 22 , 23 , 25 , 30 , 31 ]. (1996) Ewalenko et al. British Journal of Anaesthesia. Postoperative nausea and vomiting (PONV) are unpleasant, often underestimated side effects of anaesthesia and surgery, not devoid of medical complications. Prevention with antiemetics is only partially effective.

Pierre S, Corno G, Benais H, Apfel CC: A risk score-dependent antiemetic approach effectively reduces The Effect of Intravenous Midazolam on Postoperative Nausea and Vomiting:  av M Wattwil — upphov till mer postoperativt illamående än en propofolbase- lactic effect of dexamethasone on postoperative nausea and vomiting Antiemetic prophy-. Using haloperidol as an anti-emetic in palliative care: informing practice through evidence from cancer treatment and post-operative contextsYesNausea and  Dose effect for ondansetron.

It has been proposed that propofol has antiemetic effects even in nonsedative doses. The aim of this study was to investigate whether propofol influences vomiting induced by the dopamine agonist apomorphine.

The mean dose range during treatment was between 0.90 and 2.13mg/kg/h. The effect was assessed as good or very good in 91% of the patients. Antiemetic effect of propofol Antiemetic effect of propofol Montgomery, J.E.; Kf.Stin, I.G.; Sneyd, J.R. 1996-11-01 00:00:00 W.G. NOTCUTT I read with interest H.F. Seeleyâ s article (Anaesthesia 1996; 51: 571-4) on the causes and outcome of stress amongst anaesthetists.

Propofol Antiemetic effects The incidence of postoperative nausea and vomiting (PONV) is decreased with propofol administration regardless of the type of anesthetic. Nausea and vomiting in the PACU can be successfully treated with 10-20 mg of propofol IV.

Overview of antiemetic medications. • Aprepitant – NK-1 receptor antagonist. The antiemetic properties of propofol were first demonstrated by Borgeat et al.

Side effects due to perioperative use of opioids, such as postoperative nausea lidocaine, and propofol infusions (Group DL) or opioid-based anesthesia with Despite triple PONV prophylaxis, up to 42.7% of patients require antiemetic  The effect of propofol on actin, ERK-1/2 and GABAA receptor content in neurones​2007Ingår i: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN  av J Magnusson · 2019 — Maropitant has excellent antiemetic effect in cats for various types of emetic stimuli nedre magmunnen i större utsträckning än alfaxalon, tiopental och propofol. Propofol. Intravenöst anestesimedel, används rutinmässigt på op/IVA. Indikationer i palliativ vård: frisättning av noradrenalin (sympatikolytisk effect) When nothing helps:Propofol as sedative and antiemetic in palliative cancer care​. J Pain  13 jan. 2018 — Bedövningsmedel kan delas in i intravenös agenter särskilt propofol och blunda utan antiemetiska) att bestämma vilka verkningar som antiemetic och aCPT Kuhlmann, L., Liley, D. T. J. Assessing nitrous oxide effect using  av P Martner — Midazolam, yes, yes, reduces, increases.
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In a double-blind, randomized trial, Honkavaara et al.

Intralipid, the excipient of propofol, was chosen as placebo as it is devoid of antiemetic effects. Sedation scores, respiratory and cardiovascular variables, and incidence of PONV were assessed every 4 h for 24 h. Pulse oximetry and ECG were monitored continuously.
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Antiemetic Effects of Midazolam and Propofol during Spinal Anesthesia on Women Undergoing Elective Cesarean Sections. Zabetian H, Kalani N, Khalili A, Sahraei R and Radmehr M. Background and objective: Nowadays, Cesarean is the most common surgery among women, and anesthesia is an elective technique in these surgeries.

compared the antiemetic efficacy of thiopental (1.0 mg/kg) versus propofol (0.5 mg/kg) administered at the end of middle ear surgery, a procedure often associated with emetic sequelae[].The subhypnotic dose of propofol provided superior prophylaxis against retching and vomiting during the The exact mechanism by which propofol acts as an antiemetic remains unclear, but propofol is not considered to have vagolytic properties. 9 In addition, the efficacy of propofol as an antiemetic is not based on the lipid emulsion in the formulation of propofol.